Cell Culture Technician

Job Number
Job Category
Scientific Entry Level
Position Type

Job Overview

The BioCMC solutions Division, situated in Harrogate, North Yorkshire was established 20 years ago and is a fully GMP/ GLP/ GCP compliant facility providing a comprehensive portfolio of services including cell bank production and storage, cell bank and viral vector safety testing, viral clearance services, cell based bioassays, biodistribution studies, analysis of biofluids using immunochemistry based techniques and extensive protein chemistry support including cGMP batch release and stability testing.

Recent major investments have been made in facilities on the Harrogate site and successful candidates will be part of our exciting and expanding future, working with progressive management, inventive technologies and alongside other talented scientists.


Cell Culture Laboratory Technician– BioCMC Solutions

Cell Culture Technicians are laboratory based  and are responsible for performing a wide range of cell culture techniques and procedures within a regulatory compliant laboratory. They also provide operational support necessary for the performance of a wide variety of studies carried out in BioCMC. Due to the varied nature of the scientific work involved, candidates must be able to demonstrate a flexible approach to laboratory work, possess excellent communication and time management skills and be able to maintain a high standard of record keeping.

The BioCMC solutions division has three sections of analytical focus, including BioAssay, Protein Chemistry and Molecular Biology & Virology. Candidates would be required to work within the BioAssay section:



This section is subdivided into Cell Based Assays and ELISA

Cell Based Assays

This section is focused on the assessment of the biological activity of large molecules using cell-based assays. The accurate determination of the potency of a drug is necessary to release manufactured batches of the drug, assess stability (shelf life) and evaluate the impact of changes in manufacturing process or in formulation. Cell-based assays are also used as part of the immunogenicity assessment of the of large molecule drug to detect the presence of neutralising anti-drug antibodies that may be elicited in toxicology and clinical trials trial subjects in response to biological drug administration. A wide variety of cellular, biochemical and ligand/ receptor binding assays are used. The endpoint determinations of these assays include, but are not limited to; Fluorescence, Luminescence, ELISA, Flow cytometry, electrochemiluminescence (MSD) and FRET. Experience of cell culture work coupled with a good background in aseptic technique whilst working in a Class II facility would be advantageous in this section.



This section as named uses the ELISA (Enzyme-linked Immunosorbent Assay) platform to  accurately determine the potency of a drug for release of manufactured batches of the drug, assess stability (shelf life) and evaluate the impact of changes in manufacturing process or in formulation. A variety of ELISAs are used including direct, indirect and sandwich ELISAs.  Within ELISA contaminants of the drug, remaining from the purification process when manufacturing the drug, is also assessed, including Host Cell Protein and Protein A.



  • To have a good working knowledge of cell culture and procedures within relevant area
  • To support efficient running of the Cell Culture group by preparing and reviewing documents to meet operational targets of the department
  • Good working knowledge of routine use and maintenance of equipment appropriate to the relevant area
  • Good working knowledge of data processing systems within the cell culture techniques to provide accurate and consistent data for study work
  • To liaise with laboratory supervisors and BioCMC Management in order to provide basic laboratory support to aid the operation of the laboratory areas
  • Work in compliance with applicable regulatory requirements and specifically those regulations (GLP/GCP/GMP) specified in the study plans and protocols

Education / Qualifications

The postholder should ideally have a scientific background, educated to A-level (or a similar educational standard) in an appropriate scientific discipline


The postholder should typically have:


  • Computing skills, including word processing and use of spreadsheets (e.g. Word and Excel)
  • An understanding of Health and Safety policies, Company Policies and Procedures, ISO (accreditation and application) and GxPs
  • Be able to communicate effectively at all levels with other Covance employees as well as suppliers


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